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Mississippi State (5-4) fell short against Arkansas last week and will have another challenging SEC West matchup this weekend. The Bulldogs will hit the road to take on No. 17 Auburn (6-3) following its loss to No. 11 Texas A&M. The Tigers have only lost to No. 1 Georgia at Jordan-Hare Stadium. Can the visitors hand them their second home defeat of the season?

Kickoff is set for noon ET. Caesars Sportsbook lists the Tigers as 4.5-point favorites in the latest Auburn vs. Mississippi State odds. The over-under for total points is set at 51, down one point from the opening line. Before locking in any Mississippi State vs. Auburn predictions, you need to see what the red-hot SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 11 of the 2021 season on a 31-20 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Mississippi State vs. Auburn and just locked in its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Now, here are several college football odds and betting lines for Auburn vs. Mississippi State:

  • Mississippi State vs. Auburn spread: Tigers -4.5 
  • Mississippi State vs. Auburn over-under: 51 points 
  • Mississippi State vs. Auburn money line: Tigers -200, Bulldogs +170
  • MSU: The Bulldogs are 5-1 ATS in their previous six road games 
  • AUB: The Tigers are 5-1 straight up in their last six home games against Mississippi State

Why Mississippi State can cover

Mike Leach's Air Raid offense is difficult to slow down. The Bulldogs have the fifth-most passing yards in the FBS. Will Rogers' efficiency under center has powered their passing success. His proficiency has broken down opposing secondaries all year.

Rogers has thrown for 3,307 yards this year. Only two quarterbacks top that mark, but they can't match his accuracy. Rogers has a 75.2 percent completion rate and has thrown for 23 touchdowns with eight interceptions. Rogers has amassed 1,628 passing yards and 14 passing touchdowns in four road games. His road production has helped Mississippi State stay close against quality opponents. The Bulldogs haven't lost by more than three points as visitors this season.

Why Auburn can cover

The Tigers, who are 4-1 at home this season, have held plenty of success preventing teams from scoring through the air lately. They haven't allowed a passing touchdown in two games. That bodes well for a matchup against a pass-first offense like MSU. 

Auburn held Ole Miss's Matt Corral to zero passing touchdowns for the first time this season two weeks ago. The Tigers held No. 11 Texas A&M to no offensive touchdowns the following week. Putting together those back-to-back performances against ranked teams is no small feat. If Auburn keeps up its defensive intensity this weekend, it'll be difficult for the Mississippi State to put points on the board.

How to make Mississippi State vs. Auburn picks

SportsLine's model is leaning under on the total, projecting 46 combined points. It also has generated an against-the-spread pick that cashes in 60 percent of simulations. You can only get the model's Auburn vs. Mississippi State picks and prediction at SportsLine.

So who wins Mississippi State vs. Auburn? And which side of the spread hits 60 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college football picks, and find out.